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Increased density of perivascular adrenergic innervation in tibial and vagus nerves of spontaneously hypertensive rats
Author(s) -
Koistinaho J.,
Wadhwani K. C.,
Rapoport S. I.
Publication year - 1989
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490240312
Subject(s) - adrenergic , medicine , vagus nerve , anatomy , sympathetic innervation , receptor , stimulation
Adrenergic innervation of epiperineurial arterioles and of the endoneurium of the tibial and vagus nerves of spontaneously hypertensive rats (SHR) and normotensive controls. (WKY) was studied by glyoxylic acid‐induced fluorescence and paraformaldehyde‐induced fluorescence methods. Adrenergic perivascular innervation of epiperineurial arterioles in both nerves was denser in SHR than in controls. Mean density in the endoneurium also was higher in SHR in both nerve types. These results suggest that adrenergic perivascular innervation, which may influence nerve blood flow, becomes greater in density in peripheral nerves during chronic hypertension.