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Suppression of MYC by high expression of NMYC in human neuroblastoma cells
Author(s) -
Breit S.,
Schwab M.
Publication year - 1989
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490240105
Subject(s) - neuroblastoma , transfection , downregulation and upregulation , gene , biology , gene duplication , cancer research , gene expression , n myc , cell culture , microbiology and biotechnology , genetics , ganglioneuroma
Members of the MYC gene family, including MYC , NMYC , and LYMC , have been found amplified and expressed at high level in various human cancers. We have analysed the expression of two members of the MYC gene family, NMYC and MYC , in human and murine neuroblastoma cells. Whenever NMYC and MYC are co‐expressed, MYC expression predominates. Cells carrying high expression of NMYC as result of amplification lack MYC expression. The same is true for neuroblastoma cells in which expression of a single‐copy NMYC is upregulated or into which a vector forcing high expression of an exogenous NMYC had been introduced by transfection. Our studies indicate a regulatory interaction between MYC and NMYC in neuroblastoma cells.