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Chronic L‐deprenyl does not alter the restoration of striatal dopamine in MPTP‐lesioned mice
Author(s) -
Wiener H. L.,
Hashim A.,
Lajtha A.,
Sershen H.
Publication year - 1989
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490230312
Subject(s) - mptp , dopamine , dopaminergic , monoamine oxidase , selegiline , monoamine oxidase b , pharmacology , medicine , striatum , chemistry , endocrinology , parkinson's disease , enzyme , biochemistry , disease
Abstract The present study examined the effect of chronic L‐deprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP; 2 × 30 mg/kg s.c.). In the MPTP‐lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L‐deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16‐week period, and did not alter the rate of restoration of the level of striatal dopamine.