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Human fetal schwann cells in culture: Phenotypic expressions and proliferative capabibility
Author(s) -
Kim S. U.,
Yong V. W.,
Watabe K.,
Shin D. H.
Publication year - 1989
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490220107
Subject(s) - laminin , biology , monoclonal antibody , schwann cell , antigen , microbiology and biotechnology , immunology , phenotype , neural cell adhesion molecule , major histocompatibility complex , mitosis , hla dr , cell adhesion , antibody , cell , genetics , gene , extracellular matrix
In this report we examined the phenotypic expressions and the proliferative capability of cultured human fetal Schwann cells. Antigens that were expressed included laminin, nerve growth factor receptor, neural cell adhesion molecule, S‐100 protein, and that recognized by the monoclonal antibody HNK‐1. In addition, HLA‐A,B,C and HLA‐DR, respectively, class I and class II antigens of the major histocompatibility complex, were demonstrated on Schwann cells. Mitotic capability was high, with an average of 34% of Schwann cells undergoing proliferation over a 2‐day period.