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Secreted peptides as regulators of neuron–glia and glia–glia interactions in the developing nervous system
Author(s) -
Giulian D.,
Vaca K.,
Johnson B.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490210240
Subject(s) - neurite , biology , neuroscience , fibroblast growth factor , neuroglia , neuron , nervous system , microbiology and biotechnology , central nervous system , regulator , in vitro , biochemistry , receptor , gene
Abstract Secreted peptides of the nervous system help to regulate neuron–glia and glia–glia interactions during development. These regulatory factors, referred to as glia‐promoting factors (GPFs), act on specific classes of glia and include oligodendroglia‐stimulating peptides, interleukin‐1 (IL‐1), colony‐stimulating factors (CSF), and fibroblast growth factor (FGF). The maturity of secretory and target cells determines, in part, the ability of a factor to influence glial proliferation, activation, or differentiation. During neural development, GPFs help to control such fundamentally important events as cell movement, neurite outgrowth, and myelination.