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Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
Author(s) -
Graeber M. B.,
Streit W. J.,
Kreutzberg G. W.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490210104
Subject(s) - axotomy , microglia , microbiology and biotechnology , monocyte , complement receptor , macrophage , receptor , monoclonal antibody , antigen , biology , chemistry , complement system , antibody , immunology , inflammation , in vitro , biochemistry , regeneration (biology)
Axotomy of the rat facial nerve leads to mitotic divisions of microglial cells without developing into phagocytes. In order to study the functional characteristics of those activated, i.e., proliferating but nonphagocytic, microglia we investigated the expression of monocyte/macrophage antigens by these cells. Our results show that activated microglia lack monocyte/macrophage antigens recognized by the monoclonal antibodies Ox‐41, ED1, ED2, and Ki‐M2R but express high levels of CR3 complement receptors in situ.