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GM1 ganglioside protects nucleus basalis from excitotoxin damage: Reduced cortical cholinergic losses and animal mortality
Author(s) -
Mahadik S. P.,
Vilim F.,
Korenovsky A.,
Karpiak S. E.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490200411
Subject(s) - ibotenic acid , nucleus basalis , choline acetyltransferase , acetylcholinesterase , cholinergic , cerebral cortex , aché , neuroscience , cortex (anatomy) , cholinergic neuron , striatum , biology , chemistry , medicine , central nervous system , biochemistry , dopamine , enzyme
Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the frontolateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of cortical acetylcholinesterase, choline acetyltransferase, and lowered animal mortality.