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Number of olfactory marker protein‐containing receptor cells is influenced by developmental stage of the olfactory bulb
Author(s) -
Chuah M. I.,
Au C.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490200112
Subject(s) - olfactory bulb , olfactory system , biology , olfactory marker protein , olfactory mucosa , receptor , microbiology and biotechnology , embryo , olfactory receptor , central nervous system , immunohistochemistry , nervous system , olfactory ensheathing glia , in vitro , olfactory epithelium , neuroscience , immunology , biochemistry
In vitro studies on E15 rat embryos have shown that the number of receptor neurons containing olfactory marker protein (OMP) is markedly increased when olfactory mucosa (OM) is cultured in direct contact with the presumptive olfactory bulb (POB). This facilitatory influence is tissue‐specific; that is, it is absent when the POB is substituted with other nervous or non‐nervous tissues. In the present quantitative immunohistochemical study, we show that the enhancing influence of the POB is also a stage‐specific phenomenon. The number of OMP‐containing receptor cells is greatest when E15 OM is cultured with POB of the same age. If the POB was taken from a less mature (E13) or from a more mature (E17) embryo, the number of OMP‐containing cells was greatly reduced.