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Taurine and nifedipine protect retinal rod outer segment structure altered by removal of divalent cations
Author(s) -
LópezEscalera R.,
Morán J.,
PasantesMorales H.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490190413
Subject(s) - divalent , nifedipine , taurine , chemistry , biophysics , retinal , biochemistry , pharmacology , calcium , biology , amino acid , organic chemistry
A protective effect of taurine on morphological alterations induced in isolated ROS by remotion of divalent cations is described. ROS damage is not observed when sodium or chloride is replaced by impermeant ions or in the presence of nifedipine (10μM). An increase acccumulation of 22 Na but not of 36 CI occurs in retinas incubated in dicalent cation free medium. Taurine (5–25mM) provides a concentration‐dependent protection to ROS structure. Taurine is also able to reduce the increased 22 Na influx to control values. These results suggest an interaction with calcium sites on ROS membranes which regulate sodium premeability.