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Distribution of glutamic acid decarbocylase and gamma‐aminobutyric acid in thehypoglossal nucleus in the rat
Author(s) -
Aldes L. D.,
Chronister R. B.,
Marco L. A.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490190309
Subject(s) - nucleus , glutamate decarboxylase , hypoglossal nucleus , immunocytochemistry , gamma aminobutyric acid , chemistry , distribution (mathematics) , dorsum , gabaergic , staining , neuroscience , anatomy , biology , biophysics , endocrinology , biochemistry , inhibitory postsynaptic potential , receptor , enzyme , mathematical analysis , genetics , mathematics
Immunocytochemistry was used to investigate the distribution of glutamic acid decarboxylase (GAD) and gamma‐aminobutyric acid (GABA) in the hupoglossal nucleus (XII) of the adult rat. The distribution of GAD and GABA was found to be co‐extensive throughout XII. Although immunoreactivity was moderately dense in all regions, the intensity of staining was greatest in the ventral district of XII particularly ventromedially in the caudal half of the nucleus. Immunoreactive terminal‐like profiles were observed around motoneuron somata and dendrites. There also was evidence of sparse mediolaterally‐oriented densities of immunoreactivety at the junction of XII and the dorsal vagal nucleus and between dorsal and ventral districts of XII. In addition, neurons staining positive for GABA were found scattered within XII laterally and immediately outside of XII in and around the nucleus of Roller. These observations suggest a complex, differential distribution of GABA in XII and are discussed in relation to tongue motor behavior.