Regulation of the number of α‐bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist | Zendy

Smilowitz H. | Zendy; Smart E. | Zendy; Bowik C. | Zendy; Chang R.J. | Zendy

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Regulation of the number of α‐bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist

Author(s) -

Smilowitz H.,

Smart E.,

Bowik C.,

Chang R.J.

Publication year - 1988

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490190307

Subject(s) - nisoldipine , antagonist , dihydropyridine , myogenesis , calcium channel , endocrinology , calcium , medicine , chemistry , myocyte , biology , pharmacology , nifedipine , biochemistry , receptor

Calcium has been suggested as the second messenger link between skeletal muscle activity and AchR gene expression and synthesis. We have compared the concentrations of the Ca 2+ channel antagonists D600 and nisoldipine needed both to block Ca 2+ uptake into cultured myotubes and to increase AchR expression. The good correspondence between these two measurements and the use of the highly specific Ca 2+ channel antagonist nisoldipine strengthens the hypothesis that antagonist nisoldipine strengthens the hypothesis that AchR expression is regulated by levels of intracellular Ca 2+ .

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