Premium
Regulation of the number of α‐bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist
Author(s) -
Smilowitz H.,
Smart E.,
Bowik C.,
Chang R.J.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490190307
Subject(s) - nisoldipine , antagonist , dihydropyridine , myogenesis , calcium channel , endocrinology , calcium , medicine , chemistry , myocyte , biology , pharmacology , nifedipine , biochemistry , receptor
Calcium has been suggested as the second messenger link between skeletal muscle activity and AchR gene expression and synthesis. We have compared the concentrations of the Ca 2+ channel antagonists D600 and nisoldipine needed both to block Ca 2+ uptake into cultured myotubes and to increase AchR expression. The good correspondence between these two measurements and the use of the highly specific Ca 2+ channel antagonist nisoldipine strengthens the hypothesis that antagonist nisoldipine strengthens the hypothesis that AchR expression is regulated by levels of intracellular Ca 2+ .