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Dopamine and serotonin inhibition of neurite elongation of different identified neurons
Author(s) -
McCobb D. P.,
Haydon P. G.,
Kater S. B.
Publication year - 1988
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490190104
Subject(s) - neurite , serotonin , dopamine , neuroscience , elongation , chemistry , neuron , pharmacology , biology , biochemistry , receptor , in vitro , materials science , ultimate tensile strength , metallurgy
Abstract This study demonstrates that a second classical neurotransmitter, dopamine, can act to suppress regenerative neurite outgrowth. Single identified neurons were dissected from two central ganglia of the snail Helisoma , and growth cone motility was studied as neurites regenerated in cell culture. Both dopamine and serotonin inhibited growth cone motility and elongation of neurites. Outgrowth inhibition ranged from sustained arrest to a similar but transient response. The effects of dopamine and serotonin are neuron‐selective. Specific neurons affected by dopamine and serotonin represent distinct sets. One neuron was found that response to both agents. The implications of neurotransmitter regulation of the dynamics of neuronal morphology are discussed.