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Alterations in the adenylate cyclase‐cAMP‐phosphodiesterase system in the locus coeruleus during the development of spontaneous hypertension of the rat
Author(s) -
Bahner U.,
Schmid G.,
Geiger H.,
Heidland A.,
Palkovits M.
Publication year - 1987
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490180314
Subject(s) - locus coeruleus , adenylate kinase , cyclase , endocrinology , medicine , phosphodiesterase , stimulation , gtp' , basal (medicine) , chemistry , biology , central nervous system , enzyme , biochemistry , receptor , insulin
The quantitatively most important noradrenergic cell group of the brain is the locus coreruleus. Significantly increased cAMP concentration could be measured in spontaneously hypertensive rats in comparison to normotensive Wistar‐Kyoto control rats at every stage investigated. Furthermore, both the basal activity and maximal stimulation of Ca ++ ‐and GTP‐dependent adenylate cyclase as well as phosphodiesterase activity were significantly decreased in the spontaneously hypertensive rats at 14 weeks of age. The possible role of the locus coeruleus in spontaneous hypertension is presumed in counterrgulatory mechanisms against rising blood pressure.