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Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes
Author(s) -
Pixley S. K. R.,
NietoSampedro M.,
Cotman C. W.
Publication year - 1987
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490180304
Subject(s) - neurite , laminin , astrocyte , microbiology and biotechnology , neuroscience , adhesion , chemistry , biology , central nervous system , extracellular matrix , biochemistry , in vitro , organic chemistry
Astrocytes from either fetal or newborn rat brain adhered preferentially to surfaces coated with active laminin. Neurites from septal neurons did not show a preference for active over inactive laminin. However, when given a choice between laminin and an astrocytic surface, septal cells preferred to extend neurities over astroglial processes. Hence, laminin paths can guide astrocyte migration, which, in turn, can guide neurite elongation.