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Preproenkephalin mRNA in T‐Cells, macrophages, and mast cells
Author(s) -
Martin J.,
Prystowsky M. B.,
Angeletti R. H.
Publication year - 1987
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490180114
Subject(s) - mastocytoma , messenger rna , mast cell , northern blot , microbiology and biotechnology , cell culture , rna , in situ hybridization , biology , chymase , cell , dot blot , immunology , tumor cells , gene , cancer research , biochemistry , genetics
The presence of preproenkephaline mRNA in tumor cell lines derived from myeloid and mast cells was analyzed by RNA dot blot hybridization. A B‐cell lymphoma was negative for preproenkephalin mRNA, but several T‐cell lymphomas were positive. A mastocytoma and two macrophage cell lines were found to have high levels of preproenkephalin mRNA. Purified natural macrophages and mast cells also possessed easily detectable levels of this mRNA.