Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells | Zendy

Yu A. C. H. | Zendy; Chan P. H. | Zendy; Fishman R. A. | Zendy

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Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells

Author(s) -

Yu A. C. H.,

Chan P. H.,

Fishman R. A.

Publication year - 1987

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490170414

Subject(s) - glutamate receptor , granule (geology) , glutamine , cerebellum , arachidonic acid , granule cell , astrocyte , gamma aminobutyric acid , glutamic acid , biology , chemistry , microbiology and biotechnology , neuroscience , biochemistry , central nervous system , amino acid , dentate gyrus , receptor , enzyme , paleontology

The effects of arachidonic acid (20:4) on the uptake of glutamate were studied in primary cultures of cerebellar granule cells and were compared to cortical neurons and astrocytes. At a dose of 0.005 mM, the glutamate uptake was significantly inhibited in cerebellar granule cells. This inhibition was dose and time dependent. The uptake of glutamate was equally sensitive to 20:4 in primary cell cultures of cortical neurons, whereas the uptake in astrocytes was much less sensitive to 20:4. Glutamine uptake was inhibited by 20:4 in cultured cerebellar granule cells and cerebral cortical astrocytes but was not affected in cerebral cortical neurons. Furthermore, the uptake of gammaaminobutyric acid was not affected by 20:4 in cerebellar granule cells.

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