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Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury
Author(s) -
NietoSampedro M.,
Berman M. A.
Publication year - 1987
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490170303
Subject(s) - neuroscience , interleukin 1β , medicine , interleukin , pharmacology , immunology , biology , cytokine
Extracts of injured rat brain contained molecules that shared biological and physicochemical properties with interleukin‐1 (IL‐1). Brain IL‐1‐like activity increased following brain injury in parallel with the increase in astrocyte and fibroblast mitogenic activity. After 3 days postlesion, it reached about 20 times the basal (noninjured) level. Monoclonal antibodies to human IL‐1 inhibited this brain IL‐1‐like activity. One of the cellular sources of brain IL‐1‐like activity seems to be astroglial cells. Primary cultures of purified rat brain astrocytes secreted into the culture medium more IL‐1 activity than comparable numbers of peripheral blood monocytes. Brain IL‐1, as well as authentic monocyte IL‐1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture.