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A reinterpretation of tyramine sympathomimetic effect and tachyphylaxis
Author(s) -
Raiteri M.,
Levi G.
Publication year - 1986
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490160211
Subject(s) - tyramine , tachyphylaxis , chemistry , ephedrine , pharmacology , octopamine (neurotransmitter) , medicine , endocrinology , biochemistry , receptor , serotonin
In this commentary, the indirect sympathomimetic effect of tyramine and the phenomenon of tyramine tachiphylaxis are reinterpreted in terms of carriermediated excahange processes. Extracellular tyramine would exchange with intraterminal noradrenaline and, upon repeated tyramine administration, with a mixture of noradrenaline and tyramine progressively more enriched in the pharmacologically inactive amine.