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Effect of morphine‐induced cortical excitation on spinal sensory transmission
Author(s) -
Hernandez A.,
SotoMoyano R.
Publication year - 1986
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490150211
Subject(s) - somatosensory system , spinal cord , sensory system , morphine , neuroscience , stimulation , cerebral cortex , hindlimb , somatosensory evoked potential , rhythm , sensory cortex , electrophysiology , secondary somatosensory cortex , central nervous system , chemistry , anesthesia , medicine , anatomy , psychology
Bioelectrical responses evoked in the ventrolateral funiculus (VLF) of the spinal cord by electrical stimulation of the contralateral hind limb were studied following topical application of 1% morphine solution to the somatosensory SI area of the rat cerebral cortex. After morphine, a typical pattern was observed in the electrocorticogram, characterized by the appearance of rhythmic spiking activity. Time‐related with each cortical spike, a significant reduction in the amplitude of VLF responses was observed. It is concluded that cortical excitation induced by morphine generates descending influences having the ability to inhibit spinal sensory transmission.