Effect of morphine‐induced cortical excitation on spinal sensory transmission | Zendy

Hernandez A. | Zendy; SotoMoyano R. | Zendy

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Effect of morphine‐induced cortical excitation on spinal sensory transmission

Author(s) -

Hernandez A.,

SotoMoyano R.

Publication year - 1986

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490150211

Subject(s) - somatosensory system , spinal cord , sensory system , morphine , neuroscience , stimulation , cerebral cortex , hindlimb , somatosensory evoked potential , rhythm , sensory cortex , electrophysiology , secondary somatosensory cortex , central nervous system , chemistry , anesthesia , medicine , anatomy , psychology

Bioelectrical responses evoked in the ventrolateral funiculus (VLF) of the spinal cord by electrical stimulation of the contralateral hind limb were studied following topical application of 1% morphine solution to the somatosensory SI area of the rat cerebral cortex. After morphine, a typical pattern was observed in the electrocorticogram, characterized by the appearance of rhythmic spiking activity. Time‐related with each cortical spike, a significant reduction in the amplitude of VLF responses was observed. It is concluded that cortical excitation induced by morphine generates descending influences having the ability to inhibit spinal sensory transmission.

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