Premium
Stimulation of oligodendrocytes by extracts from astrocyte‐enriched cultures
Author(s) -
Bhat S.,
Pfeiffer S. E.
Publication year - 1986
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490150103
Subject(s) - oligodendrocyte , stimulation , astrocyte , immunofluorescence , biology , microbiology and biotechnology , indirect immunofluorescence , function (biology) , neuroscience , immunology , myelin , central nervous system , antibody
A soluble, heat‐labile, trypson‐sensitive factor present in extracts of astrocyteenriched cultures enhances the expression of myelination‐associated events in rat brain cultures enriched in oligodendrocytes. Both the number of oligodendrocytes detected by immunofluorescence microscopy and the levels of biochemical activities associated with oligodendrocyte differentiation increased in the cultures in respose to the extract in a time‐ and concentration‐dependent fashion. The possible significance of these studies of normal oligodendrocytes function, and thus myelination, is discussed.