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Response to gallamine: An indicator of diminished neuromuscular function in experimental autoimmune myasthenia gravis
Author(s) -
Hinman C. L.,
Dambach G. E.,
Hudson R. A.,
Rauch H. C.
Publication year - 1985
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490140212
Subject(s) - myasthenia gravis , gallamine triethiodide , acetylcholine receptor , acetylcholine , neostigmine , medicine , neuromuscular junction , neuromuscular transmission , endocrinology , chemistry , receptor , biology , neuroscience
A test for diminished neuromuscular function in animals with experimental autoimmune myasthenia gravis is described. Within minutes following an injection of gallamine triethiodide, mice exhibit a dramatic yet transient response which is dose‐dependent. Mice previously inoculated with acetylcholine receptor are approximately twice as sensitive to gallamine as normal mice. Positive results have been found in over 80% of receptor‐inoculated BALB/c mice and in 94% of C57B1/6 mice.