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Effect of pyridoxine deficiency in young rats on high‐affinity serotonin and dopamine receptors
Author(s) -
Paulose C. S.,
Dakshinamurti K.
Publication year - 1985
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490140211
Subject(s) - ketanserin , serotonin , 5 ht receptor , receptor , endogenous agonist , pyridoxine , endocrinology , dopamine , medicine , chemistry , neurotransmitter , dopamine receptor , 5 ht2 receptor , spiperone , biology , dopamine receptor d1
Abstract The high‐affinity bindings of [ 3 H]‐5‐hydroxytryptamine to serotonin S‐l receptors, [ H]‐ketanserin to serotonin S‐2 receptors in the cerebral cortex, [ 3 H]‐fluphenazine to dopamine D‐l receptors, and [ 3 H]‐spiroperidol to dopamine D‐2 receptors in the corpus striatum were studied in pyridoxine‐deficient rats and compared to pyridoxine‐supplemented controls. There was a significant increase in the maximal binding (B max ) of serotonin S‐l and S‐2 receptors with a significant decrease in their binding affinities (K d ). However, there were no significant changes either in the maximal binding or binding affinity of striatal dopamine D‐1 and D‐2 receptors. Receptor sensitivity seems to correlate negatively with the corresponding neurotransmitter concentrations in the pyridoxine‐deficient rats.