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Modulation of anterior pituitary dopamine receptors by estradiol 17‐β: Dose‐response relationship
Author(s) -
Ali S.F.,
Peck E.J.
Publication year - 1985
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490130404
Subject(s) - endocrinology , medicine , dopaminergic , dopamine , dopamine receptor , ovariectomized rat , anterior pituitary , hypothalamus , muscarinic acetylcholine receptor , estrogen , receptor , chemistry , estrogen receptor , biology , hormone , cancer , breast cancer
Exposure of ovariectomized rats to estradiol‐17‐β for 48–96 hr resulted in a dose‐dependent reduction in the number but not the K d of D‐2 dopamine receptors of the anterior pituitary. No influence of estrogen was observed on dopamine or muscarinic acetylcholine receptors of caudate or hypothalamus. The dose‐response relationship observed suggested that the influence of estrogen is directly on the pituitary, not secondary to the alteration of dopaminergic systems in the hypothalamus.