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The effect of nerve lesions on the inflammatory response to injury
Author(s) -
Helme R.D.,
Andrews P.V.
Publication year - 1985
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490130311
Subject(s) - denervation , capsaicin , medicine , inflammatory response , anesthesia , nerve injury , hydroxydopamine , inflammation , surgery , dopamine , dopaminergic , receptor
The effects of surgical denervation, capsaicin, and 6‐Hydroxydopamine pretreatment on the inflammatory response to thermal injury have been investigated in the rat. Surgical denervation and capsaicin pretreatment reduced the cellular and exudative reactions to the injury. 6‐Hydroxydopamine appeared to have a selective effect on the exudative reaction only. The effects of surgical denervation are partly explained by local and systemic effects of the procedure.