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An analysis of peripheral neuronal survival factors present in muscle
Author(s) -
Bonyhady R.E.,
Hendry I.A.,
Hill C.E.,
Watters D.J.
Publication year - 1985
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490130303
Subject(s) - skeletal muscle , biology , sensory system , cardiac muscle , medicine , peripheral , endocrinology , chemistry , microbiology and biotechnology , neuroscience
Extracts of bovine heart, rat heart, and rat skeletal muscle were chromatographically separated and the fractions tested for their ability to maintain the survival of dissociated sympathetic, parasympathetic, and sensory neurones. Bovine heart contained at least five, rat heart at least six, and rat skeletal muscle at least four active components differing in their physicochemical properties and their target selectivity. Bovine and rat heart appeared to contain at least two components in common. The differences in active components found in the three tissues are consistent with a complex and perhaps tissue‐specific system regulating neuronal survival.