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β‐Adrenergic and muscarinic cholinergic receptors: Overlap in their genetic determination
Author(s) -
Nagy A.,
Reilly M.,
Lajtha A.
Publication year - 1984
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490120409
Subject(s) - muscarinic acetylcholine receptor , cholinergic , receptor , adrenergic receptor , acetylcholine receptor , adrenergic , biology , endocrinology , medicine , chemistry , genetics
Significant positive correlation between the ligand binding values for β‐adrenergic receptors and those for muscarinic cholinergic receptors was found in five inbred strains of mice (r = 0.84) and in different vertebrate species (r = 0.99). Comparative analysis of analogous receptor studies done on various brain regions in other laboratories revealed high positive correlation between regional binding values for these two receptors. In conjunction with the work presented here, an overlap in the genetic determination of β‐adrenergic and muscarinic cholinergic receptors is suggested.