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Can functional reorganization of area 17 following monocular deprivation be modified by GM1 internal ester treatment?
Author(s) -
Carmignoto G.,
Canella R.,
Bisti S.
Publication year - 1984
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490120230
Subject(s) - monocular deprivation , kitten , ocular dominance , visual cortex , monocular , stimulation , neuroscience , sensory deprivation , biology , anatomy , medicine , sensory system , optics , cats , physics
It has been extensively reported that monocular exposure early in life leads to profound alterations in visual cortical areas, where the majority of cells become responsive only to the stimulation of the normal eye. We have investigated a possible effect of the monosialoganglioside internal ester, termed AGF 2 , on the neuronal cortical plasticity of the kitten's visual cortex following monocular deprivation. Results indicate that in monocularly deprived kittens treated with ganglioside the ocular dominance shift in favor of the normal eye is partially prevented.