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Antagonistic effects of taurine and 4‐aminopyridine on guinea pig ileum
Author(s) -
Arzate M. E.,
Ponce H.,
PasantesMorales Herminia
Publication year - 1984
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490110307
Subject(s) - taurine , acetylcholine , medicine , endocrinology , contracture , glycine , chemistry , ileum , guinea pig , atropine , basal (medicine) , amino acid , biochemistry , biology , genetics , insulin
The effects of 4‐aminopyridine (4‐AP) and of taurine on the guinea pig ileum were examined. Four‐AP increases the basal activity from 1.3 to 6.45 cm 2 /min. This effect is atropine‐sensitive and calcium‐dependent. Taurine counteracts the effects of 4‐AP on muscle contracture in a concentration‐dependent manner. In muscles preincubated with 20 mM taurine, the effect of 4‐AP decreased about 65%. Taurine added at the time of maximal effect of 4‐AP reduced the muscle contracture induced by the drug to the basal levels. Glycine and β‐alanine did not influence the contracture induced by 4‐AP, whereas 25 mM γ‐aminobutyric acid (GABA) reduced it by 30%. Taurine reduced the basal muscle activity by 50% but did not affect the contracture induced by exogenously applied acetylcholine.