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Glycoprotein properties of benzodiazepine receptors from calf cerebral cortex
Author(s) -
ShermanGold Rivka,
Dudai Y.
Publication year - 1983
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490100105
Subject(s) - receptor , wheat germ agglutinin , lectin , biochemistry , chemistry , photoaffinity labeling , concanavalin a , agglutinin , cerebral cortex , periodate , benzodiazepine , soybean agglutinin , biology , endocrinology , in vitro
Several lectins (concanavalin A, wheat germ agglutinin, wax bean agglutinin, and phytohemagglutinin) induce aggregation and precipitation of deoxycholate‐solubilized benzodiazepine receptors from calf cerebral cortex. These receptors were also retained on columns of immobilized lectins. Photoaffinity labeling of the soluble benzodiazephine receptors prevented their interaction with lectins. Periodate treatment caused inactivation of benzodiazepine receptors which was partially prevented by diazepam and/or γ‐aminobutyric acid. The possible association of the drug‐binding site and the carbohydrate moiety is discussed.