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Effect of undernutrition on some enzymes of purine metabolism in different regions of developing rat brain
Author(s) -
Vanella A.,
Barcellona M. L.,
Avitabile M.,
Avola R.,
Ragusa N.,
Serra I.,
Giuffrida A. M.
Publication year - 1983
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490090210
Subject(s) - inosine , hypoxanthine , purine nucleoside phosphorylase , biochemistry , purine , adenosine deaminase , enzyme , adenylate kinase , amp deaminase , purine metabolism , metabolism , adenosine , chemistry , nucleotide , biology , gene
The effect of undemutrition on the activity of some enzymes involved in purine metabolism, ie, adenosine aminohydrolase, adenylate aminohydrolase, and inosine phosphorylase in cerebral hemispheres, cerebellum, and brain stem of rats at different days of postnatal development was studied. Adenosine aminohydrolase, adenylate aminohydrolase, and inosine phosphorylase were assayed by radiochemical methods which involve the measurement of the radioactive products formed, ie, inosine, IMP, and hypoxanthine, respectively. The results obtained indicate that undemutrition affects the activity of the enzymes which control the concentration of purine nucleotides to a different degree in the three brain regions examined.