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Nerve growth factors in chick tissues
Author(s) -
Ebendal Ted,
Hedlund KjellOlof,
Norrgren Gunilla
Publication year - 1982
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490080206
Subject(s) - nerve growth factor , embryo , embryonic stem cell , biology , microbiology and biotechnology , nerve fiber , anatomy , endocrinology , antibody , medicine , neuroscience , immunology , biochemistry , receptor , gene
Bioassays of factors promoting nerve growth in embryonic ganglia are described. Chick embryo extract evokes fiber outgrowth in both sympathetic and ciliary ganglia explanted into a collagen gel. The response is not suppressed by antibodies directed against mouse nerve growth factor (NGF). Chick embryo extract also supported survival of neurons in both intact and dissociated ganglia. In addition to these non‐NGF activities, preliminary evidence is presented for the release of a NGF‐like factor from cultured iris of the adult chick.