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Constancy of adult hypothalamic tyrosine hydroxylase after gonadal steroid treatment during development
Author(s) -
Vaccari Andrea,
Biassoni Roberto
Publication year - 1982
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490080105
Subject(s) - medicine , endocrinology , sexual dimorphism , tyrosine hydroxylase , hypothalamus , androgen , steroid , estrogen , sex steroid , sexual differentiation , biology , tyrosine , hormone , dopamine , biochemistry , gene
Abstract Tyrosine hydroxylase (TH) was studied in the entire hypothalamus of 60‐day‐old male and female rats, and its activity was similar in both sexes. Administration of estrogen or androgen to male or female pups soon after birth and during development did not affect the kinetic parameters of TH. It is, thus, suggested that sexual dimorphism in the levels and turnover of catecholamines (CA) and their sensitivity to fluctuations in gonadal steroids during development do not depend on corresponding sex‐related or steroid‐sensitive differences in the synthesis of hypothalamic CA.