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Effect of ischemia and hypoxia on rat brain glycolipids
Author(s) -
DomańskaJanik K.,
Strosznajder J.,
Zalewska T.
Publication year - 1982
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490070402
Subject(s) - hypoxia (environmental) , ischemia , glycolipid , chemistry , brain ischemia , brain tissue , biochemistry , oxygen , medicine , endocrinology , biology , organic chemistry
Hypoxia and ischemia produced the changes in the rat brain lipid composition. Moderate decreases in the content of phospholipids, cerebrosides, and gangliosides were observed. Three different experimental models of oxygen deficiency varied as to the degree of energy disturbances were correlated with their effect on the particular lipid classes. The decrease of cerebrosides content, but not gangliosides and phospholipids, could be attributed directly to energy disturbances and concomitant restriction of glucose supply to the hypoxic‐ischemic brain.