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Reversible dissociation of a bovine cardiac factor that supports survival of avian ciliary ganglionic neurones
Author(s) -
Bonyhady Rae E.,
Hendry Ian A.,
Hill Caryl E.
Publication year - 1982
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490070103
Subject(s) - dissociation (chemistry) , molecular mass , microbiology and biotechnology , biology , medicine , endocrinology , chemistry , biophysics , biochemistry , enzyme
The relationships has been sttudied between a high and a low molecular weight form of a bovine cardiac factor that supports the survival of avian ciliary ganglionic neurones in culture. Reversible dissociation of the high molecular weight from into identical or similarly sized subunits of apparent molecular weight in the range 15,000–30,000 has been demonstrated. In addition, other inactive high molecular weight components of cardiac extract were found to interact synergistically with both active forms of the factor.