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Effect of hypoxia on the incorporation of [2‐ 3 H]glycerol and [1‐ 14 C]‐palmitate into lipids of various brain regions
Author(s) -
Alberghina M.,
Giuffrida A. M.
Publication year - 1981
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490060315
Subject(s) - phosphatidylethanolamine , phosphatidylcholine , myelin , mitochondrion , biochemistry , glycerol , metabolism , in vivo , pi , lipid metabolism , cerebellum , hypoxia (environmental) , brainstem , phospholipid , biology , chemistry , endocrinology , oxygen , central nervous system , membrane , microbiology and biotechnology , organic chemistry , neuroscience
The lipid metabolism in guinea pig brain after intermittent hypoxia, prolonged for 80 hrs, was markedly impaired. The in vivo incorporation of [2‐ 3 H]glycerol and [1‐ 14 C]palmitate into lipids of microsomes, mitochondria, myelin, and synaptosomes, purified from cerebral hemispheres, was significantly lower in the hypoxic animals than in the controls. The same effect was observed on the incorporation of labeled precursors into lipids of mitochondria purified from cerebellum and brainstem. In particular, the labeling of the major phospholipids present – ie, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) – in the mitochondria of the three brain regions examined decreased after hypoxic treatment.