Premium
The role of cAMP in the induction of ornithine decarboxylase by nerve and epidermal growth factors
Author(s) -
Lacorbiere Monique,
Schubert David
Publication year - 1981
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490060207
Subject(s) - ornithine decarboxylase , ornithine decarboxylase antizyme , biology , neuroscience , pharmacology , microbiology and biotechnology , enzyme , biochemistry
Nerve growth factor (NGF), epidermal growth factor (EGF), adenosine 3′,5′‐cyclic monophosphate (cAMP), and cholera toxin all increase the specific activity of ornithine decarboxylase (ODC) in the PC12 nerve‐like cell line. A phosphodiesterase inhibitor augments the effect of NGF on the induction of ODC in these cells, while it is only additive with the EGF response. These data suggest that cAMP has an intermediary role in the induction of ODC by NGF and that cAMP is not involved in the EGF response.