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The K + liquid ion exchange electrode system: Responses to drugs and neurotransmitters
Author(s) -
Kuramoto T.,
Haber B.
Publication year - 1981
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490060105
Subject(s) - electrode , chemistry , acetylcholine , ion , extracellular , glass electrode , electrode potential , ion exchange , choline , biophysics , inorganic chemistry , reference electrode , biochemistry , pharmacology , electrochemistry , organic chemistry , biology
K + ‐sensitive liquid ion exchange electrode systems respond with a slow potential change to acetylcholine, choline, anticholinergic drugs, biogenic amines, and glutamic acid. The response threshold has been defined, and in most cases it is at extremely low concentrations (10 −7 –10 −;5 M). The direction of the potential change varies, but in most instances it is additive to that produced by external K + . The K + electrode system is further sensitive to decreasing pH, within a narrow and possibly physiological range of pH. These findings suggest that small measured changes in extracellular K + are biased by the chemosensitivity of the liquid ion exchange electrode system to some compounds of physiological importance.