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Effect of peptides of bovine myelin basic protein on dermal fibroblasts
Author(s) -
Chiang T. M.,
Whitaker J. N.,
Seyer J. M.,
Kang A. H.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050509
Subject(s) - myelin basic protein , myelin , chemistry , microbiology and biotechnology , computational biology , biology , neuroscience , central nervous system
Bovine basic protein (BP) was digested with purified bovine brain cathepsin D to produce well defined BP derived peptides 1–42, 43–88, 43–169, and 89–169. BP and these BP peptides were tested for their effects on cultured human dermal fibroblasts using a concentration range of 0.01–1,000 ng/ml. No effect was found on cellular proliferation, and neither total protein nor collagen synthesis was altered in the presence of these substances. Although preparations of brain which contain a fibroblast‐growth factor also contain BP peptides, these results indicate that the purified BP peptides studied have no detectable biological effect on the growth of human dermal fibroblasts.