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Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: Comparative study in normal, quaking and jimpy mice
Author(s) -
Dupouey P.,
Lucas C. V.,
Gomes D.,
Jacque C.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050504
Subject(s) - glial fibrillary acidic protein , immunohistochemistry , gfap stain , myelin , myelin basic protein , pathology , biology , neuroscience , medicine , central nervous system
The topographical distribution of myelin basic protein (MBP) and of glial fibrillary acidic protein (GFA) have been compared in the CNS of 18‐day‐old normal, quaking, and jimpy mice using indirect immunofluorescence. Comparison was made in brain and spinal cord sections. MBP was strongly decreased in quaking and jimpy mice in all parts of the CNS. A pronounced gliosis was observed in jimpy mice with occurrence of numerous hypertrophied astrocytes. To a lesser extent, an astrocytic reaction was also observed in quaking CNS.