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Induction of pinocytosis in cerebral vessels by acute hypertension and by hyperosmolar solutions
Author(s) -
Hansson HansArne,
Johansson Barbro B.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050303
Subject(s) - pinocytosis , blood–brain barrier , medicine , leakage (economics) , tight junction , vesicle , biophysics , pharmacology , anesthesia , chemistry , membrane , biochemistry , biology , central nervous system , endocytosis , receptor , economics , macroeconomics
A new approach is described to study the mechanism of protein leakage through the endothelial cells in acute hypertension and after intracarotid infusion of hyperosmolar solutions. The luminal surface of the cerebrovascular endothelial cells was labeled with choleragenoid‐peroxidase before the blood‐brain barrier (BBB) dysfunction was induced. Numerous pinocytotic vesicles and some trans‐endothelial channels were formed and showed labeling of parts of their membranes. Our results indicate that the mechanism behind the protein leakage induced by hypertension and by hyperosmolar solutions is the same – ie, transendothelial pinocytosis.