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The interrelation between brain PO 2 and NADH oxidation‐reduction state in the gerbil
Author(s) -
Mayevsky A.,
Lebourdais S.,
Chance B.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050302
Subject(s) - gerbil , chemistry , hemodynamics , oxygen , vasodilation , oxygen tension , cortical spreading depression , anesthesia , medicine , endocrinology , ischemia , organic chemistry , migraine
The present investigation was aimed at studying the interrelation between hemodynamic, metabolic and oxygen tension in the brain of the gerbil exposed to various physiological and pathological conditions in the awake and anesthetized states. The hemodynamic and metabolic activities were evaluated by the DC fluorometer/reflectometer and were correlated to the pO 2 values obtained by a surface electrode. When the awake brain was exposed to spreading depression (SD), a typical oxidation cycle of the NADH was recorded concomitant with a decrease cycle of the pO 2 . Under anesthetic effect the same dip in pO 2 response was found but the NADH showed a “reduction cycle.” The pO 2 values were in a very good correlation with the changes in the reflectance trace, namely, the pO 2 was a good indicator of the vasoconstriction‐vasodilatation responses under various conditions. The same model was used under hypoxic and ischemic conditions, as well as under the effects of anesthetics.