Premium
Increased activity of a phospholipid base‐exchange system by the differentiation of neoplastic cells from the nervous system
Author(s) -
Erkell L. J.,
de Medio G. E.,
Haglid K.,
Porcellati G.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050205
Subject(s) - ethanolamine , clone (java method) , serine , phospholipid , biochemistry , cell culture , chemistry , neuroblastoma , cell , membrane , enzyme , biology , microbiology and biotechnology , gene , genetics
The activity of a base‐exchange enzyme system, specific for the polar headgroups of brain phospholipids, was measured in both C 1300 mouse neuroblastoma (clone 41 A3) and human glioma 138 MG cell lines. This base‐exchange is thought to occur between free nitrogenous bases and membrane‐bound phospholipids. The incorporation of free 14 C‐labeled ethanolamine and L‐serine was determined in undifferentiated and morphologically differentiated cells. Both cell lines showed a significant increase in ethanolamine and L‐serine incorporation upon differentiation.