Premium
Effects of anesthetics on sulfate transport in the red cell
Author(s) -
Makriyannis Alexandros,
Fesik Stephen W.
Publication year - 1980
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490050105
Subject(s) - sulfate , chemistry , anesthetic , mechanism of action , general anesthetics , red blood cell , red cell , mechanism (biology) , pharmacology , anesthesia , biophysics , biochemistry , medicine , biology , in vitro , organic chemistry , philosophy , epistemology
We have measured the effect of anesthetics on sulfate transport in the human erythrocyte and have found that a wide variety of chemical classes of anesthetics, including the anesthetic steroid alphaxalone, inhibit sulfate transport in human erythrocytes at concentrations paralleling the concentrations that block nerve conduction. These experiments suggest that anesthetics act through a general mechanism and that the sulfate transport system in the red blood cell is a good model for studying the mechanism of action of anesthetics.