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High‐energy phosphate compounds and some glycolytic substrates in the rat brain during hypoxia
Author(s) -
BroniszewskaArdelt Barbara,
Sikorska Marianna
Publication year - 1979
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490040404
Subject(s) - hypoxia (environmental) , glycolysis , lactic acid , phosphate , resuscitation , energy metabolism , chemistry , biochemistry , medicine , endocrinology , metabolism , biology , anesthesia , oxygen , bacteria , organic chemistry , genetics
The influence of acute and prolonged (with resuscitation) hypoxia, upon some glycolytic substrates and high energy phosphate compounds in the rat brain, was studied. Acute hypoxia decreased the content of glucose and glucose‐6‐phosphate as well as of high energy phosphate compounds. Simultaneously, an increase of lactic acid level was recorded. Some adaptation features could be observed, when 30‐minute hypoxia with resuscitation was studied. Brain content of high energy compounds returned to the normal value, while that of glucose increased twice over control. However, the level of lactic acid was still increased.