Premium
Pyridine nucleotide oxidation‐reduction state of the cerebral cortex in the awake gerbil
Author(s) -
Mayevsky Avraham
Publication year - 1978
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490030508
Subject(s) - gerbil , cerebral cortex , reduction (mathematics) , nucleotide , chemistry , cortex (anatomy) , pyridine , anesthesia , neuroscience , medicine , biochemistry , biology , medicinal chemistry , mathematics , gene , ischemia , geometry
A new approach to study the effect of ischemia on the brain of the awake gerbil is described. The measurement of NADH fluorescence from the surface of the cortex is done by a time‐sharing fluorometer/reflectometer connected to the brain via a flexible light guide and an implanted cannula. The response of the gerbil brain to anoxia and spreading depression is described. By unilateral occlusion of the carotid artery and increase in NADH was measured in the ipsilateral hemisphere.