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Response of a brain protein fraction 24 hours after training in rats
Author(s) -
Hydéan Holger,
Lange Paul W.
Publication year - 1976
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490020513
Subject(s) - hippocampus , thalamus , valine , endocrinology , cortex (anatomy) , medicine , chemistry , biology , biochemistry , neuroscience , amino acid
The aim of the study was to follow the amount and incorporation of 14 C‐valine into separate, soluble protein fractions of the hippocampus, thalamus, and visual cortex of rats from 0 to 72 hr after training. The behavioral test consisted of reversal of handedness with training twice daily for 25 min for 2 days, followed by a 5‐day intermission without training, and a final session of 25 min. The animals were injected intraperitoneally with 14 C‐valine 30 min before sacrifice and taken 0, 24, 48, and 72 hr after last training. After 24 hr, and only at that time, double incorporation values and increased amounts were observed in a protein fraction, No. 6 from the front, in all three brain areas of the trained rats compared to active controls. At 48 hr this protein fraction was at control level.