Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts | Zendy

Abood Leo G. | Zendy; Atkinson Holly G. | Zendy; Macneil Mary | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts

Author(s) -

Abood Leo G.,

Atkinson Holly G.,

Macneil Mary

Publication year - 1976

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490020511

Subject(s) - opiate , (+) naloxone , stereospecificity , morphine , membrane , chemistry , pharmacology , potency , heroin , trypsin , medicine , in vitro , biochemistry , opioid , drug , enzyme , receptor , catalysis

Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a K d of 9 · 10 –9 M. In most respects the binding characteristics resemble those of snyaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca 2+ and Na + ; and sensitivity to phospholipases and tryspin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research