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Behavioral effects and binding affinities of two stereoisomeric psychotomimetic glycolates
Author(s) -
Lowy Karl,
Abood Leo G.,
Raines Holly
Publication year - 1976
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490020206
Subject(s) - chemistry , cats , psychotomimetic , pharmacology , atropine , affinities , stereochemistry , anesthesia , biochemistry , medicine , nmda receptor , receptor
A comparison was made of the behavioral effects in cats of the dextro and levo isomers of 3‐quinuclidinyl benzilate (QB), using a special computer‐controlled program. Such psychophysical parameters as rate of response and tendency to use the left or right paw for lever pressing were used primarily to evaluate drug efficacy. The drug did not alter auditory threshold or the percentage of errors in level pressing. The l‐isomer was found to be at least 100 times as potent as the d‐isomer, the effects of both being qualitatively similar. After a single dose of 5μ/Kg of 1‐QB, the cat' performance did not return to normal until 5–7 days late. Pretreatment of the cats with a dose of 2 mg/Kg of atropine, an antimuscarinic agent, did not prevent the behavioral effects of 1‐QB. The binding affinity of the two isomers for synaptic membranes and phosphatidyl serine was identical.