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Hippocampal subregional volume changes in elders classified using positron emission tomography‐based Alzheimer's biomarkers of β‐amyloid deposition and neurodegeneration
Author(s) -
Busatto Filho Geraldo,
Duran Fabio Luiz de Souza,
Squarzoni Paula,
Coutinho Artur Martins Novaes,
Rosa Pedro Gomes Penteado,
Torralbo Leticia,
Pachi Clarice Gameiro da Fonseca,
Costa Naomi Antunes,
Porto Fabio Henrique de Gobbi,
Carvalho Cleudiana Lima,
Brucki Sonia Maria Dozzi,
Nitrini Ricardo,
Forlenza Orestes Vicente,
Leite Claudia da Costa,
Buchpiguel Carlos Alberto,
Paula Faria Daniele
Publication year - 2021
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24739
Subject(s) - subiculum , neurodegeneration , hippocampal formation , dementia , cognitive decline , psychology , hippocampus , hyperintensity , positron emission tomography , temporal lobe , neuroscience , pathology , medicine , magnetic resonance imaging , chemistry , disease , dentate gyrus , radiology , epilepsy
Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of β‐amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD ( n = 35) or amnestic mild cognitive impairment ( n = 39), and cognitively unimpaired subjects (either sex; n = 26) using [ 11 C]PIB‐PET to assess β‐amyloid aggregation (A+) and [ 18 F]FDG‐PET to account for neurodegeneration ((N)+). Magnetic resonance imaging‐based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)− categories, subicular volumes were inversely correlated with the degree of Aβ deposition. The A−(N)+ subgroup showed reduced HSV relative to the A−(N)− subgroup also in the subiculum/presubiculum. Combining all (N)− subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A− classification (controlling for WMH load); these between‐group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)− categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)− subjects in direct proportion to the degree of Aβ deposition. The meaningful HSV reductions detected in the A−(N)+ subgroup highlights the strength of biomarker‐based classifications outside of the classical AD continuum.