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Partial deletion of p75 NTR in large‐diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo
Author(s) -
Qin Zuoheng,
Gonsalvez David G.,
Wood Rhian J.,
Daemi Fatemeh,
Yoo Sangwon,
Ivanusic Jason J.,
Coulson Elizabeth J.,
Murray Simon S.,
Xiao Junhua
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24665
Subject(s) - neuroscience , sensory neuron , low affinity nerve growth factor receptor , dorsal root ganglion , neuron , sensory system , peripheral nervous system , myelin , biology , sciatic nerve , neurotrophin , motor neuron , peripheral , peripheral myelin protein 22 , central nervous system , medicine , receptor , anatomy , spinal cord , biochemistry
The p75 neurotrophin receptor (p75 NTR ) is required for maintaining peripheral sensory neuron survival and function; however, the underlying cellular mechanism remains unclear. The general view is that expression of p75 NTR by the neuron itself is required for maintaining sensory neuron survival and myelination in the peripheral nervous system (PNS). Adopting a neuronal‐specific conditional knockout strategy, we demonstrate the partial depletion of p75 NTR in neurons exerts little influence upon maintaining sensory neuron survival and peripheral nerve myelination in health and after demyelinating neuropathy. Our data show that the density and total number of dorsal root ganglion (DRG) neurons in 2‐month‐old mice is not affected following the deletion of p75 NTR in large‐diameter myelinating neurons, as assessed by stereology. Adopting experimental autoimmune neuritis induced in adult male mice, an animal model of demyelinating peripheral neuropathy, we identify that deleting p75 NTR in myelinating neurons exerts no influence upon the disease progression, the total number of DRG neurons, and the extent of myelin damage in the sciatic nerve, indicating that the expression of neuronal p75 NTR is not essential for maintaining peripheral neuron survival and myelination after a demyelinating insult in vivo . Together, results of this study suggest that the survival and myelination of peripheral sensory neurons is independent of p75 NTR expressed by a subtype of neurons in vivo . Thus, our findings provide new insights into the mechanism underpinning p75 NTR ‐mediated neuronal survival in the PNS.